- Manchester United boss Ruben Amorim aims for derby win at the Etihad Stadium
- Wolves host Ipswich in a vital game at the bottom of the table
- Free-scoring Chelsea and Brentford meet at Stamford Bridge on Sunday night

The big game of the Premier League weekend takes place at the Etihad Stadium on Sunday as struggling Manchester City host Ruben Amorim's Manchester United.

Leaders Liverpool, fresh from a sixth straight Champions League win on Tuesday evening, host Fulham on Saturday and Wolves and Ipswich, two of the bottom three, meet in a colossal clash at Molineux.

James Milton gives his score predictions for all 10 matches in week 16 of the Premier League season.

Arsenal vs Everton (Saturday, 3pm)

Everton thumped struggling Wolves 4-0 in their last Premier League game, but they had failed to score in their previous four matches and may struggle to land a blow on Arsenal, who have won their last three home matches to nil.

Score prediction: Arsenal 2-0 Everton

Liverpool vs Fulham (Saturday, 3pm)

Fulham have scored in all but one of their 15 Premier League games this term, including a 1-1 draw with Arsenal last weekend, so leaders Liverpool may have to work hard for a home win over the Cottagers.

Score prediction: Liverpool 2-1 Fulham

Newcastle vs Leicester (Saturday, 3pm)

Leicester roared back from 2-0 down to claim a 2-2 draw with Brighton last time out and Ruud van Nistelrooy's men could be involved in another entertaining draw at Newcastle, who have conceded seven goals in their last two matches.

Score prediction: Newcastle 2-2 Leicester

Wolves vs Ipswich (Saturday, 3pm)

Wolves and Ipswich are both desperate for a victory at Molineux, but the Premier League strugglers may have to settle for a point apiece.

There should be goals as the hosts have the worst defensive record in the division and Town have scored five times in their last three away matches.

Score prediction: Wolves 2-2 Ipswich

Nottingham Forest vs Aston Villa (Saturday, 5.30pm)

Nottingham Forest and Aston Villa are level on 25 points from 15 games and the draw looks a big runner at the City Ground.

Six of Forest's seven wins have come against teams in the bottom eight and Villa, going well in the Champions League, are a better calibre of opponent.

Score prediction: Nottingham Forest 1-1 Aston Villa

Brighton vs Crystal Palace (Sunday, 2pm)

This fixture is traditionally tight, but Brighton thrashed Crystal Palace 4-1 at the Amex Stadium in February and they can frank that form against their rivals this weekend.

Score prediction: Brighton 3-1 Crystal Palace

Man City vs Man United (Sunday, 4.30pm)

The Manchester giants have both had patchy Premier League campaigns, but favourites City, who suffered a 2-0 defeat to Juventus in the Champions League on Wednesday, should be backed to grind out a narrow derby win.

Score prediction: Man City 2-1 Man United

Chelsea vs Brentford (Sunday, 7pm)

Chelsea start this round of fixtures as the leading scorers in the division with 35 goals, but Brentford have found the net 31 times and the Bees can play their part in a cracking encounter in west London.

Score prediction: Chelsea 3-2 Brentford

Southampton vs Tottenham (Sunday, 7pm)

Tottenham had a Europa League trip to Rangers on Thursday. but their talented forwards should still be too slick for bottom club Southampton, who lost 5-1 to Chelsea in their last home fixture.

Score prediction: Southampton 1-4 Tottenham

Bournemouth vs West Ham (Monday, 8pm)

Bournemouth's last four home results include wins over Arsenal, Man City and Spurs in which they conceded only one goal. The Cherries can stand firm to claim another victory on their own patch against an inconsistent West Ham side.

Score prediction: Bournemouth 1-0 West Ham