The North London derby headlines Premier League Matchday 6 as second-place Tottenham make the short journey to the Emirates.

Manchester City will aim to extend their 100% start to the campaign against Nottingham Forest while Liverpool host West Ham.

We run through the key stats ahead of a bumper weekend of Premier League action.

Crystal Palace vs Fulham (Saturday, 3pm)

There is no Friday night or Saturday lunchtime top-flight action this weekend so this London derby is among the first batch of matches.

Crystal Palace have only been beaten by Manchester City and Arsenal in their last 12 home games so are in good enough form to end their three-match winless run against Fulham.

The visitors have just a 9% away win rate in London derbies in their Premier League history.

Luton vs Wolves (Saturday, 3pm)

Luton are the first team since Swindon in 1993 to lose their first four matches as a Premier League side.

Rob Edwards' men are aiming to avoid becoming the sixth team in the division's history to lose their first five games of the season — and Wolves' away form offers some hope.

The West Midlanders have won just four of their last 29 league away games, losing six of their last seven.

Manchester City vs Nottingham Forest (Saturday, 3pm)

Victory for Manchester City at the Etihad on Saturday would mark just the second time in Premier League history that they have won their opening six matches.

And considering that Nottingham Forest have never won a Premier League game against a team sitting top of the league, City will fancy their chances.

The visitors pose a threat, however, with Nigerian striker Taiwo Awoniyi involved in at least one goal in his last nine league appearances.

Brentford vs Everton (Saturday, 5.30pm, Sky Sports)

Brentford host Everton with history on their side, having avoided defeat in their last four home matches against the Toffees.

Thomas Frank's side have held a lead in 15 of their last 16 home league games — including in all of their last 10 — although they have ended up drawing their last three.

Saturday's visitors have made their joint-worst start to a Premier League campaign, picking up one point from their opening five games.

Burnley vs Manchester United (Saturday, 8pm, TNT Sports)

Manchester United are aiming to avoid conceding at least two goals in five straight league games for the first time since 1977.

But their head-to-head record is decent against Burnley, who have won only one of their last 15 Premier League matches against the Red Devils.

The Clarets are on the verge of losing their opening four home league games of a campaign for the first time ever.

Arsenal vs Tottenham (Sunday, 2pm, Sky Sports)

Both teams are unbeaten heading into the North London derby for the first time since September 1990.

The Gunners are aiming to win their third straight league match against Spurs for the first time since a run of five victories between 1987-1989.

Tottenham have won just one of their last 30 league games at their fierce foes (11 draws, 18 defeats) and are winless since a 3-2 victory at the Emirates in November 2010.

Brighton vs Bournemouth (Sunday, 2pm)

Brighton are the Premier League's entertainers, with their five matches featuring a league-high 22 goals so far this season.

The Seagulls are the top scorers in the division with 15 ahead of the weekend's action, while they have both netted and conceded in their last nine league outings.

Bournemouth have scored seven and conceded 10 goals in six matches in all competitions this season so this looks set to be an entertaining match-up.

Chelsea vs Aston Villa (Sunday, 2pm)

Aston Villa are aiming to make it back-to-back wins at Chelsea for the first time in more than 90 years when they travel to West London on Sunday.

And they have a decent chance, considering the Blues have lost more home matches in 2023 (six) than in any calendar year since 1993.

Unai Emery's side are unbeaten in London with two wins and two draws since the Spaniard took over last year.

Liverpool vs West Ham (Sunday, 2pm)

Since losing 3-0 under Brendan Rodgers in August 2015, Liverpool have won six consecutive home matches against West Ham.

That game marked the Hammers' only victory at Anfield in their last 50 attempts in the league.

David Moyes' side have won twice on the road already this season, though, including an impressive 3-1 victory at Brighton last month.

Sheffield United vs Newcastle (Sunday, 4.30pm, Sky Sports)

Newcastle are unbeaten in 14 Premier League matches against promoted sides, featuring seven wins and seven draws.

Sheffield United have only taken one point from their opening five games — but have dropped five points thanks to goals conceded in or after the 88th minute, including losing 2-1 at Tottenham from a winning position last time out.

This could be a feisty affair considering that both of these teams have picked up 17 cards in their opening five games, more than any other side.

Follow each game with our unbeatable live scores service. Simply tap the Scores tab on the web or download the LiveScore app from the App Store for iOS devices or Google Play for Android.

Win up to £250k with LiveScore 6!

LiveScore 6 is back for the new season and we have a jackpot of up to £250,000 this weekend! 

Predict the score of all six LiveScore 6 fixtures for your chance to win — and it is free to play. 18+, UK and Ireland residents only, T&Cs apply.