One person died and 21 people were injured yesterday in a shooting at the end of the Kansas City Chiefs' Super Bowl victory parade.

The Chiefs, led by quarterback Patrick Mahomes and head coach Andy Reid, won the showpiece NFL event for the second consecutive year at the expense of the San Francisco 49ers in Las Vegas on Sunday. 

But the celebrations in Kansas City were marred when multiple shots were fired near Union Station, causing panic and chaos among the crowd.

More than 800 police officers were already in the area and those nearest the scene responded immediately. The city's fire department was also on hand to provide medical assistance. 

Kansas City police chief Stacey Graves confirmed a total of 22 people were shot and three individuals were arrested, while local radio station KKFI broke the news that DJ Lisa Lopez-Galvan was killed in the shooting.

A statement from KKFI said: "It is with sincere sadness and an extremely heavy and broken heart that we let our community know that Lisa Lopez, host of Taste of Tejano, lost her life today in the shooting at the KC Chiefs' rally. 

"Our hearts and prayers are with her family. We encourage anyone who feels they saw something to reach out to law enforcement. 

"This senseless act has taken a beautiful person from her family and this KC community."

Chief nursing officer Stephanie Meyer revealed nine children aged six to 15 were taken to Children's Mercy Hospital with gunshot wounds.

She said: "The one word I would just use to describe what we saw and how they felt when they came to us was fear."

Messages of support quickly flooded social media, with Chiefs linebacker Drue Tranquill posting: "Please join me in prayer for all the victims in this heinous act.

"Pray that doctors and first responders would have steady hands and that all would experience full healing."

Kansas City mayor Quinton Lucas was inside Union Station when the sound of gunfire rang out.

He said: "I'm heartbroken and incredibly upset and disappointed.

"I was there with my wife and mother. I never would've thought that we, along with Chiefs players, fans, hundreds of thousands of people, would be forced to run for our safety.

"We went out looking for a celebration and that was marred. We are praying for the safety of everyone."

A law enforcement source told CBS News the shooting appeared to be the result of an argument that turned violent. The source said it was not related to terrorism.