After four months of intense buildup, Aaron Rodgers' first game with the New York Jets lasted all of four snaps.

Rodgers will not return to Monday's season opener against the Buffalo Bills after injuring his left ankle on the Jets' opening series, a sudden and stunning ending to one of the most anticipated player debuts with a new team in recent memory. 

Rodgers was injured when sacked by Buffalo's Leonard Floyd on New York's official third play from scrimmage. The four-time NFL MVP briefly remained on the turf holding his lower left leg before being helped to the sideline, then was later taken to the locker room on a cart.

The Jets initially announced Rodgers was questionable to return before ruling him out midway through the second quarter. The team said in a statement that X-rays on Rodgers' ankle were negative but did not elaborate further.

Zach Wilson replaced Rodgers, whose only pass of the night landed incomplete.

Rodgers put together a Hall of Fame-worthy 18-year career with the Green Bay Packers that included five All-Pro selections, 10 Pro Bowl honours and a Super Bowl title during the 2010 season in addition to his four MVP awards.

The 39-year-old requested a trade to the Jets during the offseason, which the Packers eventually agreed to on April 26.

Under terms of the trade, which included the Packers moving up from No. 15 to No. 13 in this year's draft in a swap of first-round picks, Green Bay would receive a conditional 2024 first-round choice from New York if Rodgers plays 65 per cent of the Jets' plays this season. The Packers would get a 2024 second-round pick if that condition is not met. 

With Rodgers on the roster, the Jets were a trendy preseason pick to end a longstanding playoff drought and contend for an AFC title. New York holds the NFL's longest active streak without a postseason appearance at 12 years, having last reached the playoffs in 2010.